Lap-Chee Tsui Publication Award (2013)

The Canadian Institutes of Health Research-Institute of Genetics (CIHR-IG) is pleased to announce the Lap-Chee Tsui Publication Award (2013) recipients and finalists, a prize for exceptional trainee-conducted research within the CIHR-IG's mandate.

CIHR-IG established the award to honour one of Canada's greatest researchers, Dr. Lap-Chee Tsui, whose discovery of the gene for cystic fibrosis was a milestone in human genetic disease research.

Recipient - Biomedical research:

Antonija Kreso (University Health Network)
Kreso, A., O'Brien, C. A., van Galen, P., Gan, O. I., Notta, F., Brown, A. M., Ng, K., Ma, J.,Wienholds, E., Dunant, C., Pollett, A., Gallinger, S., McPherson, J., Mullighan, C. G., Shibata, D., Dick, J. E. (2013). Variable clonal repopulation dynamics influence chemotherapy response in colorectal cancer. Science, 339(6119), 543-548.

Recipient - Clinical, health services, population health, or genetic ethical, legal and social issues research:

Alicia Semaka (University of British Columbia)
Semaka, A., Kay, C., Doty, C., Collins, J. A., Bijlsma, E. K., Richards, F., Goldberg, Y. P., Hayden, M. R. (2013). CAG size-specific risk estimates for intermediate allele repeat instability in Huntington disease. Journal of medical genetics, 50(10), 696-703.


Janet Markle (Rockefeller University)
Markle, J. G., Frank, D. N., Mortin-Toth, S., Robertson, C. E., Feazel, L. M., Rolle-Kampczyk, U., von Bergen, M., McCoy, K. D., Macpherson, A. J., Danska, J. S. (2013). Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity. Science, 339(6123), 1084-1088.

Nicholas Stephane Caron (McMaster University)
Caron, N. S., Desmond, C. R., Xia, J., Truant, R. (2013). Polyglutamine domain flexibility mediates the proximity between flanking sequences in huntingtin. Proceedings of the National Academy of Sciences, 110(36), 14610-14615.

Rina Rosenzweig (University of Toronto)
Rosenzweig, R., Moradi, S., Zarrine-Afsar, A., Glover, J. R., Kay, L. E. (2013). Unraveling the mechanism of protein disaggregation through a ClpB-DnaK interaction. Science, 339(6123), 1080-1083.

A total of 36 nominations were received, 27 in biomedical research and 9 in clinical, health services, population health, and genetic ethical, legal and social issues research. We would like to take this opportunity to thank all the nominators for their interest in this program and all the nominees for their outstanding contribution to genetic research.

For details regarding the next competition round please visit the CIHR-IG website in summer 2014:


Paul Lasko, PhD
Scientific Director
CIHR Institute of Genetics